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1

A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians

Almut Nebel, Friederike Flachsbart, Andreas Till, Amke Caliebe, Hélène Blanché, Alexander Arlt, Robert Häsler, Gunnar Jacobs, Rabea Kleindorp, Andre Franke, Binghui Shen, Susanna Nikolaus, Michael Kra

Journal:

Mechanisms of Ageing and Development

Year:

2009

Language:

english

File:

PDF, 468 KB

english, 2009

2

IL-4 signaling mechanisms in inflammatory bowel disease mononuclear phagocytes

Yvonne Rückert, Ulrike Schindler, Thomas Heinig, Susanna Nikolaus, Andreas Raedler, Dr. Stefan Schreiber

Journal:

Inflammatory Bowel Diseases

Year:

1996

Language:

english

File:

PDF, 961 KB

english, 1996

3

Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men

Frauke Friedrichs, Sonia Brescianini, Vito Annese, Anna Latiano, Klaus Berger, Subra Kugathasan, Ulrich Broeckel, Susanna Nikolaus, Mark J. Daly, Stefan Schreiber, John D. Rioux, Monika Stoll

Journal:

Year:

2006

Language:

english

File:

PDF, 292 KB

english, 2006

4

Heritability of chronic venous disease

Andreas Fiebig, Petra Krusche, Andreas Wolf, Michael Krawczak, Birgitt Timm, Susanna Nikolaus, Norbert Frings, Stefan Schreiber

Journal:

Year:

2010

Language:

english

File:

PDF, 166 KB

english, 2010

5

Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals

Flachsbart, Friederike, Caliebe, Amke, Nothnagel, Michael, Kleindorp, Rabea, Nikolaus, Susanna, Schreiber, Stefan, Nebel, Almut

Journal:

European Journal of Human Genetics

Year:

2009

Language:

english

File:

PDF, 102 KB

english, 2009

6

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Franke, Andre, Balschun, Tobias, Karlsen, Tom H, Hedderich, Jürgen, May, Sandra, Lu, Tim, Schuldt, Dörthe, Nikolaus, Susanna, Rosenstiel, Philip, Krawczak, Michael

Journal:

Nature Genetics

Year:

2008

Language:

english

File:

PDF, 259 KB

english, 2008

7

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

Franke, Andre, Balschun, Tobias, Karlsen, Tom H, Sventoraityte, Jurgita, Nikolaus, Susanna, Mayr, Gabriele, Domingues, Francisco S, Albrecht, Mario, Nothnagel, Michael, Ellinghaus, David

Journal:

Nature Genetics

Year:

2008

Language:

english

File:

PDF, 319 KB

english, 2008

8

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)

Franke, Andre, Balschun, Tobias, Sina, Christian, Ellinghaus, David, Häsler, Robert, Mayr, Gabriele, Albrecht, Mario, Wittig, Michael, Buchert, Eva, Nikolaus, Susanna

Journal:

Nature Genetics

Year:

2010

Language:

english

File:

PDF, 263 KB

english, 2010

9

Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations

Croucher, Peter J P, Mascheretti, Silvia, Hampe, Jochen, Huse, Klaus, Frenzel, Henning, Stoll, Monika, Lu, Tim, Nikolaus, Susanna, Yang, Suk-Kyun, Krawczak, Michael

Journal:

European Journal of Human Genetics

Year:

2003

Language:

english

File:

PDF, 304 KB

english, 2003

10

Ultraviolet irradiation-induced apoptosis does not trigger nuclear fragmentation but translocation of chromatin from nucleus into cytoplasm in the microglial cell-line, BV-2

Susanna Zierler, Barbara Klein, Tanja Furtner, Nikolaus Bresgen, Ursula Lütz-Meindl, Hubert H. Kerschbaum

Journal:

Year:

2006

Language:

english

File:

PDF, 2.70 MB

english, 2006

11

Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity

Friederike Flachsbart, Peter JP. Croucher, Susanna Nikolaus, Jochen Hampe, Christina Cordes, Stefan Schreiber, Almut Nebel

Journal:

Experimental Gerontology

Year:

2006

Language:

english

File:

PDF, 100 KB

english, 2006

12

Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men

Almut Nebel, Friederike Flachsbart, Arne Schäfer, Michael Nothnagel, Susanna Nikolaus, Nour Eddine El Mokhtari, Stefan Schreiber

Journal:

Mechanisms of Ageing and Development

Year:

2007

Language:

english

File:

PDF, 100 KB

english, 2007

13

Low level of the mtDNA4977 deletion in blood of exceptionally old individuals

Nicole von Wurmb-Schwark, Thorsten Schwark, Amke Caliebe, Carolin Drenske, Susanna Nikolaus, Stefan Schreiber, Almut Nebel

Journal:

Mechanisms of Ageing and Development

Year:

2010

Language:

english

File:

PDF, 293 KB

english, 2010

14

A case-only study of gene-environment interaction between genetic susceptibility variants inNOD2and cigarette smoking in Crohn's disease aetiology

Katherine L Helbig, Michael Nothnagel, Jochen Hampe, Tobias Balschun, Susanna Nikolaus, Stefan Schreiber, Andre Franke, Ute Nöthlings

Journal:

BMC Medical Genetics

Year:

2012

Language:

english

File:

PDF, 187 KB

english, 2012

15

Induction of Short Interspersed Nuclear Repeat-containing Transcripts in Epithelial Cells upon Infection with a Chicken Adenovirus

Nikolaus Wick, Susanna Luedemann, Ilja Vietor, Matt Cotten, Michael Wildpaner, Georg Schneider, Frank Eisenhaber, Lukas A. Huber

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 1004 KB

english, 2003

16

Mechanisms in failure of infliximab for Crohn's disease

Susanna Nikolaus, Andreas Raedler, Tanja Kühbacher, Nicolaos Sfikas, Ulrich R Fölsch, Stefan Schreiber

Journal:

Year:

2000

Language:

english

File:

PDF, 87 KB

english, 2000

17

Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study

Jochen Hampe, Jochen Grebe, Susanna Nikolaus, Camilla Solberg, Peter JP Croucher, Silvia Mascheretti, Jörgen Jahnsen, Björn Moum, Bodo Klump, Michael Krawczak, Muddassar M Mirza, Ulrich R Foelsch, Mor

Journal:

Year:

2002

Language:

english

File:

PDF, 93 KB

english, 2002

18

Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease

Stefan Schreiber, Susanna Nikolaus, Jochen Hampe, Jens Hämling, Irmtraut Koop, Birte Groessner, Heribert Lochs, Andreas Raedler

Journal:

Year:

1999

Language:

english

File:

PDF, 66 KB

english, 1999

19

Tumour necrosis factor inhibition by oxpentifylline and intestinal inflammation in Crohn's disease

Jürgen Bauditz, Yvonne Rückert, Andreas Raedler, Susanna Nikolaus, Herbert Lochs, Stefan Schreiber

Journal:

Year:

1995

Language:

english

File:

PDF, 160 KB

english, 1995

20

Predictors for subsequent need for immunosuppressive therapy in early Crohn's disease

Sandra Wenger, Susanna Nikolaus, Stefanie Howaldt, Bernd Bokemeyer, Andreas Sturm, Jan C. Preiss, Alain M. Schoepfer, Andreas Stallmach, Carsten Schmidt

Journal:

Journal of Crohn's and Colitis

Year:

2012

Language:

english

File:

PDF, 563 KB

english, 2012

21

Anti-TNF-α antibodies improve intestinal barrier function in Crohn's disease

Rainer Noth, Eckhard Stüber, Robert Häsler, Susanna Nikolaus, Tanja Kühbacher, Jochen Hampe, Burkhard Bewig, Stefan Schreiber, Alexander Arlt

Journal:

Journal of Crohn's and Colitis

Year:

2012

Language:

english

File:

PDF, 382 KB

english, 2012

22

463 Endoscopic Ultrasound of the Colon for the Differentiation of Crohn's Disease and Ulcerative Colitis in Comparison to Healthy Controls - A Prospective, Blinded, Comparative Study

Annette Fritscher-Ravens, Mark Ellrichmann, Susanna Nikolaus, Alexander Arlt, Petr Sergueev, Tanja Kuehbacher, Luise Wintermeyer, Stefan Schreiber, Perdita Wietzke-Braun

Journal:

Gastrointestinal Endoscopy

Year:

2011

Language:

english

File:

PDF, 64 KB

english, 2011

23

Improvement of arthritis and arthralgia after treatment with infliximab (Remicade) in a German prospective, open-label, multicenter trial in refractory Crohn’s disease

Hans Herfarth, Florian Obermeier, Tilo Andus, Gerhard Rogler, Susanna Nikolaus, Tanja Kuehbacher, Stefan Schreiber

Journal:

American Journal of Gastroenterology

Year:

2002

Language:

english

File:

PDF, 66 KB

english, 2002

24

Differential p38 mitogen-activated protein kinase target phosphorylation in responders and nonresponders to infliximab

Georg H Waetzig, Philip Rosenstiel, Susanna Nikolaus, Dirk Seegert, Stefan Schreiber

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 137 KB

english, 2003

25

The Complete Individual Genome of a Female Crohn's Disease Patient – What Can You Learn?

Andre Franke, Tanja Kuehbacher, Susanna Nikolaus, Philip C. Rosenstiel, Stefan Schreiber

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 179 KB

english, 2011

26

99 Whole Exome Sequencing of 42 Crohn's Disease Patients and Identification of Rare Variants Associated With Crohn's Disease

David Ellinghaus, Susanna Nikolaus, Philip C. Rosenstiel, Stefan Schreiber, Andre Franke

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 50 KB

english, 2012

27

1110 Microbial Pattern Recognition Causes Distinct Functional Micro-RNA Signatures in Human Monocytes

Robert Haesler, Gunnar Jacobs, Andreas Till, Nils Grabe, Christian Cordes, Susanna Nikolaus, Stefan Schreiber, Philip C. Rosenstiel

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 232 KB

english, 2012

28

Safety and Efficacy of Recombinant Human Interleukin 10 in Chronic Active Crohn's Disease

Stefan Schreiber*, Richard N. Fedorak†, Ole Haagen Nielsen§, Gary Wild‖, C.Noel Williams¶, Susanna Nikolaus*, Meron Jacyna#, Bret A. Lashner**, Alfred Gangl††, Paul Rutgeerts§§, Kim Isaacs‖‖, Sander J

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 206 KB

english, 2000

29

Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active crohn's disease

Stefan Schreiber, Susanna Nikolaus, Herbert Malchow, Wolfgang Kruis, Herbert Lochs, Andreas Raedler, Eckhart G. Hahn, Thomas Krummenerl, Gerhard Steinmann

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 229 KB

english, 2001

30

Diagnostics of Inflammatory Bowel Disease

Susanna Nikolaus, Stefan Schreiber

Journal:

Gastroenterology

Year:

2007

Language:

english

File:

PDF, 3.63 MB

english, 2007

31

Increased Response and Remission Rates in Short-Duration Crohn's Disease With Subcutaneous Certolizumab Pegol: An Analysis of PRECiSE 2 Randomized Maintenance Trial Data

Schreiber, Stefan, Colombel, Jean-Frédéric, Bloomfield, Ralph, Nikolaus, Susanna, Schölmerich, Jürgen, Panés, Julian, Sandborn, William J

Journal:

American Journal of Gastroenterology

Year:

2010

Language:

english

File:

PDF, 259 KB

english, 2010

32

PopGen: Population-Based Recruitment of Patients and Controls for the Analysis of Complex Genotype-Phenotype Relationships

Krawczak, Michael, Nikolaus, Susanna, von Eberstein, Huberta, Croucher, Peter J.P., El Mokhtari, Nour Eddine, Schreiber, Stefan

Journal:

Community Genetics

Year:

2006

Language:

english

File:

PDF, 164 KB

english, 2006

33

W1219 Genome-Wide Association Study for Ulcerative Colitis Demonstrates Novel Associations at Chromosome 22 and 7

Balschun, Tobias C., Franke, Andre, Sina, Christian, Ellinghaus, David, Mayr, Gabriele, Albrecht, Mario, Wittig, Michael, Buchert, Eva, Nikolaus, Susanna, Gieger, Christian, Wichmann, H. Erich, Svento

Journal:

Gastroenterology

Year:

2010

Language:

english

File:

PDF, 46 KB

english, 2010

34

Sa1122 Anti-TNF-Therapy in Patients With an Early Course of CrohnS Disease - A Prospective Observational Study in Germany

Bokemeyer, Bernd, Helwig, Ulf, Schmidt, Carsten, Teich, Niels, Rupf, Ann-Katrin, Krummenerl, Thomas, Hartmann, Heinz, Düffelmeyer, Marc, Nikolaus, Susanna, Hüppe, Dietrich, Schreiber, Stefan

Journal:

Gastroenterology

Year:

2013

Language:

english

File:

PDF, 198 KB

english, 2013

35

Su1079 Tryptophan Deficiency in Crohn Disease

Nikolaus, Susanna, Al-Massad, Natalie, Bethge, Johannes, Waetzig, Georg H., Rosenstiel, Philip C., Junker, Ralf, Thieme, Florian, Schreiber, Stefan

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 309 KB

english, 2014

36

Sa1294 Predictors for Subsequent Need for Immunosuppressive Therapy in Early Ulcerative Coltis

Schmidt, Carsten, Beltz, Luisa, Bokemeyer, Bernd, Hueppe, Dietrich, Kruis, Wolfgang, Nikolaus, Susanna, Preiss, Jan C., Sturm, Andreas, Teich, Niels, Stallmach, Andreas

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 50 KB

english, 2012

37

Su1279 Clinical Epidemiology of Fecal Calprotectin: Population Data From the Fire Study, a Prospective Longitudinal Study in Germany to Evaluate Fecal Calprotectin in Routine Monitoring of Crohn's Disease

Nikolaus, Susanna, Schreiber, Stefan, Nurwakagari, Pascal, Rath, Stefan, Wittig, Bianca M., Schwarz, Mario

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 352 KB

english, 2014

38

Mo1237 Pulmonary Involvement in IBD-Patients and the Effect of TNF-Alpha-Inhibitors on Pulmonary Function

Bethge, Johannes, Ellrichmann, Mark, Conrad, Claudio, Nikolaus, Susanna, Noth, Rainer, Schuldt, Dörthe, Zeissig, Sebastian, Schreiber, Stefan

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 127 KB

english, 2014

39

Sa203 Low Levels of Glucocorticoid-Use in Early CrohnS Disease in Germany

Bokemeyer, Bernd, Helwig, Ulf, Stallmach, Andreas, Teich, Niels, Halle, Ralf, Düffelmeyer, Marc, Raspe, Heiner, Prenzler, Anne, Mittendorf, Thomas, Hüppe, Dietrich, Nikolaus, Susanna, Schreiber, Stefa

Journal:

Gastroenterology

Year:

2012

Language:

english

File:

PDF, 59 KB

english, 2012

40

Su1080 Patient Education in a 14 Month Randomized Trial Fails to Improve Adherence in Ulcerative Colitis: Influence of Demographic and Clinical Parameters on Non-Adherence

Nikolaus, Susanna, Schreiber, Stefan, Siegmund, Britta, Bokemeyer, Bernd, Baestlein, Elke, Bachmann, Oliver, Kruis, Wolfgang

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 297 KB

english, 2014

41

Su1561 Endoscopic Ultrasound of the Colon for Evaluation of Mucosal Healing/Early Therapy Response of Anti-TNF-α Therapy in Patients With Ulcerative Colitis - First Results of a Pilot Study

Ellrichmann, Mark, Bethge, Johannes, Nikolaus, Susanna, Arlt, Alexander, Schreiber, Stefan, Fritscher-Ravens, Annette

Journal:

Gastrointestinal Endoscopy

Year:

2013

Language:

english

File:

PDF, 196 KB

english, 2013

42

Increased peripheral production of TNF-a and mucosal levels of activated NFkB predict relapse after treatment with infliximab in patients with Crohn's disease

Nikolaus, Susanna, Kuhbacher, Tanja, Foelsch, Ulrich R., Raedler, Andreas, Schreiber, Stefan

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 180 KB

english, 2000

43

Tu1553 Endoscopic Ultrasound of the Colon Can Differentiate Between Crohn‘S Disease and Ulcerative Colitis and Reliably Quantifies the Degree of Inflammation - a Prospective, Blinded, and Controlled Comparative Study

Ellrichmann, Mark, Bethge, Johannes, Nikolaus, Susanna, Arlt, Alexander, Kuehbacher, Tanja, Schreiber, Stefan, Wietzke-Braun, Perdita, Klapper, Wolfram, Fritscher-Ravens, Annette

Journal:

Gastrointestinal Endoscopy

Year:

2012

Language:

english

File:

PDF, 75 KB

english, 2012

44

Immunosenescence of the gi immune system: increased secretion of proinflammatory cytokines by LPMNC

Nikolaus, Susanna, Raedler, Andreas, Schreiber, Stefan

Journal:

Gastroenterology

Year:

1998

Language:

english

File:

PDF, 163 KB

english, 1998

45

Differential activity and expression of mitogen-activated protein kinases in inflammatory bowel disease

Waetzig, Georg H., Seegert, Dirk, Nikolaus, Susanna, Rosenstiel, Philip, Sfikas, Nikolaos, Schreiber, Stefan

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 189 KB

english, 2001

46

Recombinant human interferon-beta (IFNβ-1a) induces remission and is well tolerated in moderately active ulcerative colitis (UC)

Nikolaus, Susanna, Rutgeerts, Paul, Fedorak, Richard N., Steinhart, Hillary, Wild, Gary E., Theuer, Dieter, Schreiber, Stefan, Moehrte, Joerg J., Goedkoop, Rene J.

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 181 KB

english, 2001

47

Improvement of arthritis and arthralgia after treatment with infliximab (Remicade) in a German prospective, open-label, multicenter trial in refractory Crohn's disease

Herfarth, Hans, Obermeier, Florian, Andus, Tilo, Rogler, Gerhard, Nikolaus, Susanna, Kuehbacher, Tanja, Schreiber, Stefan

Journal:

American Journal of Gastroenterology

Year:

2002

Language:

english

File:

PDF, 66 KB

english, 2002

48

Comparison of two exploratory dietary patterns in association with the metabolic syndrome in a Northern German population

Barbaresko, Janett, Siegert, Sabine, Koch, Manja, Aits, Imke, Lieb, Wolfgang, Nikolaus, Susanna, Laudes, Matthias, Jacobs, Gunnar, Nöthlings, Ute

Journal:

British Journal Of Nutrition

Year:

2014

Language:

english

File:

PDF, 177 KB

english, 2014

49

1026 Changes of the Colonic Wall Structure Precede Mucosal Healing in Patients With Acute Inflammatory Bowel Disease Undergoing Anti-Integrin Therapy - Preliminary Results of a Prospective Study

Ellrichmann, Mark, Bethge, Johannes, Zeissig, Sebastian, Brandt, Berenice, Arlt, Alexander, Nikolaus, Susanna, Schreiber, Stefan

Journal:

Gastroenterology

Year:

2015

Language:

english

File:

PDF, 938 KB

english, 2015

50

210 Contrast Enhanced Endoscopic Ultrasound of the Colon Is a Marker of Early Therapy Response Following Anti-TNF-Therapy in Patients With Acute Ulcerative Colitis

Ellrichmann, Mark, Bethge, Johannes, Arlt, Alexander, Zeissig, Sebastian, Brandt, Berenice, Lankau, Janina, Nikolaus, Susanna, Schreiber, Stefan, Fritscher-Ravens, Annette

Journal:

Gastrointestinal Endoscopy

Year:

2015

Language:

english

File:

PDF, 157 KB

english, 2015